G Protein-Coupled Receptors

Welcome to the G Protein-Coupled Receptor Main Page of the Molecular Recognition Section.

Although our section is mainly involved in investigating the Molecular Recognition process between purinoceptors and their ligands, we are interested in all aspects of Molecular Recognition.

Since all currently known P₁ purinoceptor subtypes, and several P₂ purinoceptor subtypes are members of the protein family commonly known as G Protein-Coupled Receptors (GPCRs), we have collected a fair amount of data on GPCRs.

These data are organized in three sections:

GPCR sequence alignments (over 150 unique sequences), a

GPCR mutant database, and an

Introduction to Modelling GPCRs.

The coordinates of our A_2A adenosine receptor model (1MMH), and our P2Y₁ receptor model (1DDD) are available from the Protein Data Bank.

The current release of the GPCR mutant database is version 3.2.1.

There is an informal network of groups trying to work out an international standard for GPCR database formats.

The institutes participating in this effort are:

our section at NIH

GCRdB at Harvard

GPCRDB at EMBL

GRAP at the University of Tromsø

Olfactory Receptor Database at Yale

Since this is a very dynamic field with lots of opportunities, we highly value your opinion of the current servers, what changes you would like to see made, or what new services you would like to see implemented.

Please drop us a note (e-mail or snail mail) at the address below.

Also, please read our disclaimer.