Comprehensive alignment of G protein-coupled receptor sequences
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Human sequences are used for this alignment, unless noted.
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GPCRAelegans FPGGGGGFPG GGGFPGGSNT STQPHTTSNS GGGGFPGGGG FPGGGTPFTN
GRH .......... .......... .......... .......... ..........
TRH .......... .......... .......... .......... ..........
FSHprec RQ...EVDYM TQTRGQRSSL AEDNESSYSR GF........ ..........
TSHprec MQSLRQRKSV NALNSPLHQE YEENLGDSIV GYKEKSKFQD THNNAHYYVF
LH_CGprec KQCESTVRKV SNKTLYSSML AESELSGWDY EY........ ..........
PGE_EP1 .......... .......... .......... .......... ..........
PGE_EP2 .......... .......... .......... .......... ..........
PGE_EP3 .......... .......... .......... .......... ..........
PGF .......... .......... .......... .......... ..........
PGI .......... .......... .......... .......... ..........
TXA2 .......... .......... .......... .......... ..........
PAF .......... .......... .......... .......... ..........
M2 .......... .......... .......... .......... ..........
M4 .......... .......... .......... .......... ..........
M1 .......... .......... .......... .......... ..........
M3 .......... .......... .......... .......... .MTLHNNSTT
M5 .......... .......... .......... .......... ..........
H1 .......... .......... .......... .......... ..........
H2 .......... .......... .......... .......... ..........
5HT1A .......... .......... .......... .......... ..........
5HT1B .......... .......... .......... .......... ..........
5HT1D .......... .......... .......... .......... ..........
5HT1E .......... .......... .......... .......... ..........
5HT1F .......... .......... .......... .......... ..........
5HT2A .......... .......... .........M DILCEENTSL SSTTNSLMQL
5HT2B .......... .......... .......... .......... ..........
5HT2C .......... .......... .......... ......MVNL RNAVHSFLVH
5HT5A .......... .......... .......... .......... ..........
5HT5Brat .......... .......... .......... .......... ..........
5HT6rat .......... .......... .......... .......... ..........
5HT7 .......... .......... ........MM DVNSSGRPDL YGHLRSFLLP
alpha1A .......... .......... .......... .......... ..........
alpha1B .......... .......... .......... .......... ..........
alpha1C .......... .......... .......... .......... ..........
alpha2A .......... .......... .......... .......... ..........
alpha2B .......... .......... .......... .......... ..........
alpha2C1 .......... .......... .......... .......... ..........
alpha2C2 .......... .......... .......... .......... ..........
beta1 .......... .......... .......... .......... ..........
beta2 .......... .......... .......... .......... ..........
beta3 .......... .......... .......... .......... ..........
beta4turkey .......... .......... .......... .......... ..........
D1A .......... .......... .......... .......... ..........
D2 .......... .......... .......... .......... ..........
D3 .......... .......... .......... .......... ..........
D4 .......... .......... .......... .......... ..........
D5 .......... .......... .......... .......... ..........
A1 .......... .......... .......... .......... ..........
A2a .......... .......... .......... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome PSADQILFVN VTTTVAAAAL TAAAAVSTTK SGNGNAARGY TDSDDDAGMG
ACTH .......... .......... .......... .......... ..........
MSH .......... .......... .......... .......... ..........
MC3 .......... .......MSI QKKYLEGDFV FPVSSSSFLR TLLEPQLGSA
MC4 .......... .......... .......... .......... ........MV
MC5 .......... .......... .......... .......... ..........
melatonin .......... .......... .......... .......... ..........
oxytocin .......... .......... .......... .......... ..........
conopressinLs .......... .......... .......... .........M DLELNLTNGF
V1A .......... .......... .......... .......... ..........
V1B .......... .......... .......... .......... ..........
V2 .......... .......... .......... .......... ..........
CCK_A .......... .......... .......... .......... ..........
CCK_B .......... .......... .......... .......... ..........
NPY1 .......... .......... .......... .......... ..........
NTR .......... .......... .......... .......... ......MRLN
NK1 .......... .......... .......... .......... ..........
NK2 .......... .......... .......... .......... ..........
NK3 .......... .......... ....MATLPA AETWIDGGGG VGADAVNLTA
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec .......... .......... ..METLCLRA SFWLALVGCV ISDNPERYST
ET_Bprec ........MQ PPPSLCGRAL VALVLACGLS RIWGEERGFP PDRATPLLQT
ET_Cfrog .......... .......... .MATVILFVA WMACLMVGVC YQEFQTQQNF
galanin .......... .......... .......... .......... ..........
NMB .......... .......... .......... .......... ..........
GRP .......... .......... .......... .......... ..........
BRS3 .......... .......... .......... .......... ..........
deltaOP .......... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP .......... .......... .......... ........MD SSAAPTNASN
OPRX .......... .......... .......... .......... ..........
CB1 LADTTFRTIT TDLLYVGSND IQYEDIKGDM ASKLGYFPQK FPLTSFRGSP
CB2 .......... .......... .......... .......... ..........
SSTR1 .......... .......... .......... .......... ..........
SSTR2 .......... .......... .......... .......... ..........
SSTR3 .......... .......... .......... .......... ..........
SSTR4 .......... .......... .......... .......... ..........
SSTR5 .......... .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a .......... .......... .......... .......... ..........
AT1brat .......... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 .......... .......... .......... .......... ..........
P2Y7 .......... .......... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 .......... .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 .......... .......... .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec .......MGP RRLLLVAACF SLCGPLLSAR TRARRPESKA TNATLDPRSF
C5a .......... .......... .......... .......... ..........
GP01mouse .......... .......... .......... .......... ..........
R334rat .......... .......... .......... .......... ..........
GP21mouse .......... .......... .......... .......... ..........
GCRCmouse .......... .......... .......... ........MK VPPVLLLFLL
TXKR .......... .......... .......... .......... MASPAGNLSA
G10Drat .......... .......... .......... .......... ..........
RDC1 .......... .......... .......... .......... ..........
BLR1 .......... .......... .......... .......... ..........
CL5 .......... .......... .......... .......... ..........
LCR1 .......... .......... .......... .......... ..........
EBI1 .......... .......... .......... .......... ..........
RBS1rat .......... .......... .......... .......... ..........
EBI2 .......... .......... .......... .......... ..........
GCRTchick .......... .......... .......... .......... ..........
APJ .......... .......... .......... .......... ..........
RTArat .......... .......... .......... .......... ..........
UHRrat .......... .......... .......... .......... .........M
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 .......... .......... .......... .......... ..........
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .......... .......... .......... ..........
MCP-1B .......... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
51 100
GPCRAelegans QFTIPHIPNV HQSTADPPTL IPHSNHTPNG TQFHQCSKIP VQCVPKSDAF
GRH .......... ............... MANSA SPEQNQNHCS AINNSIPLMQ
TRH .......... .......... .......... ....MENETV SELNQTQLQP
FSHprec .......... .......... ...DMTYTEF DYDLCNEVVD VTCSPKPDAF
TSHprec FEEQEDEIIG FGQELKNPQE ETLQAFDSHY DYTICGDSED MVCTPKSDEF
LH_CGprec .......... .......... ...GFCLPK. .........T PRCAPEPDAF
PGE_EP1 .......MSP CGPLNLSLAG EATTCAAP.. .......... ........WV
PGE_EP2 .......... .......... ..MSTPGV.. .......... ........NS
PGE_EP3 .......... ..MGNASNDS QSEDC..E.. .......... ........TR
PGF .......... ...MSMNNSK QLVSPAAA.. .......... ........LL
PGI .......... .......... .......... .......... ......MADS
TXA2 .......... .....MWPNG SSLGPCFR.. .......... ........PT
PAF .......... .......... .......... ...M...... E.PD...HSS
M2 .......... .......... .......... ...MNNSTNS SNNSLALTSP
M4 .......... .......... .......MAN FTPVNGSSGN QSVRLVTSSS
M1 .......... .......... .......... ..MNTSAPPA VSPNITVLAP
M3 SPLFPNISSS WIHSPSDAGL PPGTVTHFGS YNVSRAAGNF SSPDGTTDDP
M5 .......... .......... .........M EGDSYHNATT VNGTPVNHQP
H1 .......... .......... .......... ..MSLPNSSC LLEDKMCEGN
H2 .......... .......... .......... .......... .MAPNGTASS
5HT1A .......... .......... ...MDVLSPG QGNNTTSPPA PFETGGNTTG
5HT1B .......... MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY
5HT1D .......... ........MS PLNQSAEGLP QEA...SNRS LNATETSEAW
5HT1E .......... .......... .......... .......MNI TNCTTEASMA
5HT1F .......... .......... .......... ......MDFL NSSDQNLTSE
5HT2A NDDTRLYSND FNSGEANTSD AFNWTVDSEN RTNLSCEGCL SPSCLSLLHL
5HT2B .....MALSY RVSELQSTIP EHILQSTFVH VISSNWSGLQ TESIPEEMKQ
5HT2C LIGLLVWQCD ISVSPVAAIV TDIFNTSDGG RFKFPDGV.. ..........
5HT5A .......... .........M DLPVNLTSFS LSTPSPLETN HSLGKDDLRP
5HT5Brat .......MEV SNLSGATPGI AFPPGPESCS DSPSSGRSMG STPGGLILSG
5HT6rat .......... .......... .......... ...MVPEPGP VNSSTPAWGP
5HT7 EVGRGLPDLS PDGGADPVAG SWAPHLLSEV TASPAPTWDA PPDNASGCGE
alpha1A .....MAAAL RSVMMAGYLS EWRTPTYRST EMVQRLRMEA VQHSTSTAAV
alpha1B .......... ..MNPDLDTG HNTSAPAHWG ELKNANFTGP NQTSSNSTLP
alpha1C .......... .......... .......... ...MVFLSGN ASDSSNCTQP
alpha2A .......... .......... ...MGSLQPD AGNASWNGTE APGGGARATP
alpha2B .......... .......... .......... .......... .......MDH
alpha2C1 ........MA SPALAAALAV AAAAGPNASG AGERGSGGVA NASGASWGPP
alpha2C2 ........MA SPALAAALAV AAAAGPNASG AGERGSGGVA NASGASWGPP
beta1 MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP
beta2 .......... .......... .MGQPGNGSA FLLAPNRSHA ....PDHDVT
beta3 .......... .......... ..MAPWPHEN SSLAPWPDLP TLAPNTANTS
beta4turkey .......... .......... .......... ......MTPL PAGNGSVPNC
D1A .......... .......... .......... ......MRTL NTSAMDGTGL
D2 .......... .......... .....MDPLN LSWYDDDLER QNWSRPFNGS
D3 .......... .......... .......... MASLSQLSSH LNYTCGAENS
D4 .......... .......... .....MGNRS TADADGLLAG RGPAAGASAG
D5 .......... .........M LPPGSNGTAY PGQFALYQQL AQGNAVGGSA
A1 .......... .......... .......... .......... ..........
A2a .......... .......... .......... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... .......MPN
OCdrome TEAVANISGS LVEGLTTVTA ALSTAQADKD SAGECEGAVE ELHASILGLQ
ACTH .......... ........MK HIINSYEN.. .......... .....INNTA
MSH ....MAVQGS QRRLLGSLNS TPTAIPQL.. .......... .....GLAAN
MC3 LLTAMNASCC LPSVQPTLPN GSEHLQAP.. .......... .....FFSNQ
MC4 NSTHRGMHTS LHLWNRSSYR LHSNASES.. .......... .....LGKGY
MC5 ......MNSS FHLHFLDLNL NATEGNLS.. .......... .....GPNVK
melatonin .......... .......... .......... ..MQGNGSAL PNASQPVLRG
oxytocin .......... ........ME GALAANWSAE AANASAAPPG AEGNRTAGPP
conopressinLs MLMPPTKRAV IQIASNEKVG YDVSKSQPVN ATTDLNTTRM NATNSTEVSY
V1A ........MR LSAGPDAGPS GNSSPWWPLA TGAGNTSREA EALGEGNGPP
V1B .......... .......... .....MDSGP LWDANPTPRG TLSAPNATTP
V2 ........ML MASTTSAVPG HPSLPSLP.. .......... ..SNSSQERP
CCK_A .......... ........MD VVDSLLVNGS NITPPCELGL ENETLFCLDQ
CCK_B .....MELLK LNRSVQGTGP GPGASLCRPG APLLNSSSVG NLSCEPPRIR
NPY1 .......... .........M NSTLFSQVEN HSVHSNFSEK NAQLLAFEND
NTR SSAPGTPGTP AADPFQRAQA GLEEALLAPG FGNASGNASE RVLAAPSSEL
NK1 .......... .......... .......MDN VLPVDSDLSP NISTNTSEPN
NK2 .......... .......... ......MGTC DIVTEANISS GPESNTTGIT
NK3 SLAAGAATGA VETGWLQLLD QAGNLSSSPS ALGLPVASPA PSQPWANLTN
blueops .......... .......... ..MRKMSEEE FYL.FKNISS V..GPWDGPQ
greenops .....MAQQW SLQRLAGRHP QDSYEDSTQS SIFTYTNSNS T.RGPFEGPN
redops .....MAQQW SLQRLAGRHP QDSYEDSTQS SIFTYTNSNS T.RGPFEGPN
rhodopsin .......... .......... ..MNGTEGPN FYVPFSNATG VVRSPFEYPQ
violetopsGg .......... .......... ....MSSDDD FYL...FTNG SVPGPWDGPQ
opsin_crab .......... ..MANQLSYS SLGWPYQPNA SVVDTMPKEM LYMIHEHWYA
ET_Aprec NLSNHVDDFT TFRGTELSFL VTTHQPTNL. ......VLPS NGSMHNYCPQ
ET_Bprec AEIMTPPTKT LWPKGSNASL ARSLAPAEVP KGDRTAGSPP RTISPPPCQG
ET_Cfrog PDISNPSQEL NQEPAHRIVQ LDSIQNNGAL NMSTGNVLNM SPPPPSPCLS
galanin .......... .......... ......MELA VGNLSEGNAS WPEPPAPEPG
NMB .......... ......MPSK SLSNLSVTTG ANESGSVPEG WERDFLPASD
GRP .......... .........M ALNDCFLLNL EVDHFMHCNI SSHSADLPVN
BRS3 .......... ..MAQRQPHS PNQTLISITN DTESSSSVVS NDNTNKGWSG
deltaOP .........M EPAPSAGAEL Q.PPLFANAS DAYPSAFPSA GANASGPPGP
kappaOP MESPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE
muOP CTDALAYSSC SPAPSPGSWV NLSHLDGNLS DPCGPNRTNL GGRDSLCPPT
OPRX ........ME PLFPAPFWEV IYGSHLQGNL SLLSPNHSLL PPHLLLNASH
CB1 FQEKMTAGDN PQLVPADQVN ITEFYNKSLS SFKENEENIQ CGENFMDIEC
CB2 .......... .......... ......MEEC WVTEIANGSK DGLDSNPMKD
SSTR1 .MFPNGTASS PSSSPSPSPG SCGEGGGSRG PGAGAADGME EPGRNASQNG
SSTR2 .......... ......MDMA DEPLNGSHTW LSIPFDLNGS VVSTNTSNQT
SSTR3 .......... .....MDMLH PSSVSTTSEP ENASSAWPPD ATLGNVSAGP
SSTR4 .......... .MSAPSTLPP GGEEGLGTAW PSAANASSAP AEAEEAVAGP
SSTR5 .......... .....MEPLF PASTPSW... .NASSPGAAS GGGDNRTLVG
IL8A .......... ......MSNI TDPQMWDFDD LN....FTGM PPADEDYSPC
IL8B .......... ......MESD SFEDFWKGED LSNYSYSSTL PPFLLDAAPC
AT1a .......... .......... .......... .MILNSSTED GIKRIQDDCP
AT1brat .......... .......... .......... .MTLNSSTED GIKRIQDDCP
AT2 .......... ....MKGNST LATTSKNITS GLHFGLVNIS GNNESTLNCS
BK1 .......... .......... ..MASSWPPL ELQSSNQSQL FPQNATACDN
BK2 .......... .......... ........ML NVTLQGPTLN GT.FAQSKCP
P2Y7 .......... .......... .......... .......... .MNTTSSAAP
P2Y6 .......... .......... .......... ...MERDNGT IQAPGLPPTT
P2Y5 .......... .......... .......... .......... .....MVSSN
P2Y4 .......... .......... ....MASTES SLLRSLGLSP GPGSSEVELD
P2Y3chick .......... .......... .......... ........MS MANFTGGRNS
P2Y2 .......... .......... ......MAAD LGPWNDTING TWDGDELGYR
P2Y1 ........MT EVLWPAVPNG TDAAFLAGPG SSWGNSTVAS TAAVSSSFKC
THRprec LLRNPNDKYE PFWEDEEKNE SGLTEYRLVS INKSSPLQKQ LPAFISEDAS
C5a .......... .......... ..MNSFNYTT PDYGHYDDKD TLDLNTPVDK
GP01mouse .......... .....MNEDP KVNLSGLPRD CIDAGAPENI SAAVPSQGSV
R334rat .......... .....MNEDP KVNLSGLPRD CIEAGTPENI SAAVPSQGSV
GP21mouse .......... ........MM WGAGSSMAWF SAGSGSV.NV SSVDPVEEPT
GCRCmouse SSVRATEQPQ VVTEHPSMEA ALTGPNASSH FWANYTFSDW QNFVGRRRYG
TXKR WPGWGWPPPA ALRNLTSSPA PTASPSPAPS WTPSPRPGPA HPFL......
G10Drat .......... MSVIPSSRPV STLAPDNDFR EIHNWTELLH LFNQTFSDCH
RDC1 .......... .....MDLHL FDYAEPGNFS DISWPCNSSD CIVVDTVMCP
BLR1 ...MNYPLTL EMDLE..NLE DLFWELDRLD NYNDTSLVEN HLCPATEGPL
CL5 .......... .......... MEGISIYTSD NYTE.EMGSG DYDSMKEPCF
LCR1 .......... .......... MEGISIYTSD NYTE.EMGSG DYDSMKEPCF
EBI1 .MDLGKPMKS VLVVALLVIF QVCLCQDEVT DDYIGDNTTV DYTLFESLCS
RBS1rat .......... .......... .......MPT SFPELDLENF EYDDSAEACY
EBI2 .......... .......... ........MD IQMANNFTPP SATPQGNDCD
GCRTchick .......... .......... .......... .......... .....MVSSN
APJ .......... .......... .......... .MEEGGDFDN YYGADNQSEC
RTArat .......... .....MAGNC SWEAHSTNQN KMCPGMSEAL ELYSRGFLTI
UHRrat TSLPPGTTGD PDLFSGPSPA GSTPANQSAE ASESNVSATV PRAAAVTPFQ
FMRL1 .......... .......... .......... ...METNFSI PLNETEEVLP
FMRL2 .......... .......... .......... ...METNFST PLNEYEEVSY
fMLP .......... .......... .......... ...METNSSL PTNISGGTPA
OLF1catfish .......... .......... ........MT SVLNALSANA TFIRPSTFYI
OLF3catfish .......... .......... ....MADNIT SILSLTSTNA TFIRPSTFYI
OLF8catfish .......... .......... .......... ....MLAPVQ NISFTTFTLT
OLF32Acatfish .......... .......... ........MS ALNSSLLQNV SFVRPEYFFI
OLF32Bcatfish .......... .......... ........MS ALNSSLLQNV SFVRPEYFFI
OLF32Ccatfish .......... .......... ........MS ALNSSLLQNV SFVRPEYFFI
OLF32Dcatfish .......... .......... ........MN ALNSSLLQNV SFVRPEYFFI
OLF47catfish .......... .......... .......... ....MNSTNS TDSFDKGFYL
OLF202catfish .......... .......... .......... ....MPEGNI TNVKNFVILG
OLFCOR1chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR2chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR3chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR4chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR5chicken .......... .......... .......... ....MALGNC TTPTTFILSG
OLFCOR6chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFdog .......... .......... .......... ....MTEKNQ TVVSEFVLLG
OLF07E .......... .......... .......... ....MDGGNQ SEGSEFLLLG
OLF07I .......... .......... .......... ....MMGQNQ TSISDFLLLG
OLF07J .......... .......... ...MLLCFRF GNQSMKRENF TLITDFVFQG
OLFOR3mouse .......... .......... .......... ....MEVDSN TSSGSFILMG
OLFrat .......... .......... .......... ...MMGTGNH SAVVVFVLVG
OLFF3rat .......... .......... .......... ...MDSSNRT .RVSEFLLLG
OLFF5rat .......... .......... .......... ....MSSTNQ SSVTEFLLLG
OLFF6rat .......... .......... .......... .MAWSTGQNL STPGPFILLG
OLFF12rat .......... .......... .......... ...MESGNST RRFSSFFLLG
OLFI3rat .......... .......... .......... ......MNNQ TFITQFLLLG
OLFI7rat .......... .......... .......... ...MERRNHS GRVSEFVLLG
OLFI8rat .......... .......... .......... ......MNNK TVITHFLLLG
OLFI9rat .......... .......... .......... ....MTRRNQ TAISQFFLLG
OLFI14rat .......... .......... .......... ....MTGNNQ TLILEFLLLG
OLFI15rat .......... .......... .......... ....MTEENQ TVISQFLLLF
OLFOR17_40 .......... .......... .......... .MQPESGANG TVIAEFILLG
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ...MAETSAL
HHRF1 .......... .......... ......MTPT TTTAELTTEF DYDEDATPCV
HHRF2 .......... .......... .........M TTSTNNQTLT QVSNMTNHTL
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .....MLSTS RSRFIRNTNE SGEEVTTFFD YDYGAPCHKF
MCP-1B .......... .....MLSTS RSRFIRNTNE SGEEVTTFFD YDYGAPCHKF
PPR1bovine .......... ......MAVE YNQSTDYYYE ENEMNDTHDY SQYEVICIKE
101 150
GPCRAelegans HPCEDIMGYV WLTVVSFMVG AVALVANLVV ALVLLTSQ.. .....RRLNV
GRH NLPTLTLSGK IRVTVTFFLF LLSATFNASF LLKLQKWTQK KEKGKKLSRM
TRH RAVVALEYQV VTILLVLIIC GLGIVGNIMV VLVVMR.... ...TKHMRTP
FSHprec NPCEDIMGYN ILRVLIWFIS ILAITGNIIV LVILTTSQYK .......LTV
TSHprec NPCEDIMGYK FLRIVVWFVS LLALLGNVFV LLILLTSHYK .......LNV
LH_CGprec NPCEDIMGYD FLRVLIWLIN ILAIMGNMTV LFVLLTSRY. ......KLTV
PGE_EP1 PNTSAVPPSG ASPALPIFSM TLGAVSNLLA LALLAQAA.G RLRRRRSATT
PGE_EP2 SASLSPDRLN SPVTIPAVMF IFGVVGNLVA IVVLCKS... ..RKEQKETT
PGE_EP3 QWLPPGE... .SPAISSVMF SAGVLGNLIA LALLARRW.R SAGRRSSLSL
PGF SNTTCQTENR LSVFFSVIFM TVGILSNSLA IAILMKAY.Q RFRQKSKA.S
PGI CRNLTYVRGS VGPATSTLMF VAGVVGNGLA LGILSARRPA RP......SA
TXA2 NITLEERRLI ASPWFAASFC VVGLASNLLA LSVLAGA... RQGGSHTRSS
PAF HMDSEFRYTL F.PIVYSIIF VLGVIANGYV LWVFARLY.P CKKFNEIK..
M2 ...YKTFEVV FIVLVAGSLS LVTIIGNILV MVSI.KVN.R HLQT.....V
M4 HNRYETVEMV FIATVTGSLS LVTVVGNILV MLSI.KVN.R QLQT.....V
M1 ..GKGPWQVA FIGITTGLLS LATVTGNLLV LISF.KVN.T ELKT.....V
M3 LGGHTVWQVV FIAFLTGILA LVTIIGNILV IVSF.KVN.K QLKT.....V
M5 LERHRLWEVI TIAAVTAVVS LITIVGNVLV MISF.KVN.S QLKT.....V
H1 KTTMASPQLM PLVVVLSTIC LVTVGLNLLV LYAVRSER.. KLHT.....V
H2 FCLDSTACKI TITVVLAVLI LITVAGNVVV CLAVGLNR.. RLRN.....L
5HT1A ISDVTVSYQV ITSLLLGTLI FCAVLGNACV VAAIALER.. SLQN.....V
5HT1B QDSISLPWKV LLVMLLALIT LATTLSNAFV IATVYRTR.. KLHT.....P
5HT1D DPRTLQALKI SLAVVLSVIT LATVLSNAFV LTTILLTR.. KLHT.....P
5HT1E IRPKTITEKM LICMTLVVIT TLTTLLNLAV IMAIGTTK.. KLHQ.....P
5HT1F ELLNRMPSKI LVSLTLSGLA LMTTTINSLV IAAIIVTR.. KLHH.....P
5HT2A QEKN...... WSALLTAVVI ILTIAGNILV IMAVSLEK.. KLQN.....A
5HT2B IVEEQGNKLH WAALLILMVI IPTIGGNTLV ILAVSLEK.. KLQY.....A
5HT2C ..QN...... WPALSIVIII IMTIGGNILV IMAVSMEK.. KLHN.....A
5HT5A SSPLLSVFGV LILTLLGFLV AATFAWNLLV LATILRVR.. TFHR.....V
5HT5Brat REPPFSAFTV LVVTLLVLLI AATFLWNLLV LVTILRVR.. AFHR.....V
5HT6rat GPPPAPGGSG WVAAALCVVI VLTAAANSLL IVLICTQP.. AVRN.....T
5HT7 QINYGRVEKV VIGSILTLIT LLTIAGNCLV VISVCFVK.. KLRQ.....P
alpha1A GGLVVSAQGV GVGVFLAAFI LMAVAGNLLV ILSVACNR.. HLQT.....V
alpha1B ..QLDITRAI SVGLVLGAFI LFAIVGNILV ILSVACNR.. HLRT.....P
alpha1C PAPVNISKAI LLGVILGGLI LFGVLCNILV ILSVACHR.. HLHS.....V
alpha2A ...YSLQVTL TLVCLAGLLM LLTVFGNVLV IIAVFTSR.. ALKA.....P
alpha2B QDPYSVQATA AIAAAITFLI LFTIFGNALV ILAVLTSR.. SLRA.....P
alpha2C1 RGQYSAGAVA GLAAVVGFLI VFTVVGNVLV VIAVLTSR.. ALRA.....P
alpha2C2 RGQYSAGAVA GLAAVVGFLI VFTVVGNVLV VIAVLTSR.. ALRA.....P
beta1 EPLSQQWTAG M.GLLMALIV LLIVAGNVLV IVAIAKTP.. RLQT.....L
beta2 QQRDEVWVVG M.GIVMSLIV LAIVFGNVLV ITAIAKFE.. RLQT.....V
beta3 GLPGVPWEAA LAGALLALAV LATVGGNLLV IVAIAWTP.. RLQT.....M
beta4turkey SWAAVLSRQW AVGAALSITI LVIVAGNLLV IVAIAKTP.. RLQT.....M
D1A VVERDFSVRI LTACFLSLLI LSTLLGNTLV CAAVIRFR.. HLRSK....V
D2 DGKADRPHYN YYATLLTLLI AVIVFGNVLV CMAVSREK.. ALQT.....T
D3 TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKER.. ALQT.....T
D4 ASAGLAGQGA AALVGGVLLI GAVLAGNSLV CVSVATER.. ALQT.....P
D5 GAPPLGPSQV VTACLLTLLI IWTLLGNVLV CAAIVRSR.. HLRAN....M
A1 MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQ.. ALRD.....A
A2a ...MPIMGSS VYITVELAIA VLAILGNVLV CWAVWLNS.. NLQN.....V
A2b ..MLLETQDA LYVALELVIA ALSVAGNVLV CAAVGTAN.. TLQT.....P
A3 NSTTLSLANV TYITMEIFIG LCAIVGNVLV ICVVKLNP.. SLQT.....T
OCdrome LAVPE.WEAL LTALVLSVII VLTIIGNILV ILSVFTYK.. PLRI.....V
ACTH RNNSDCPRVV LPEEIFFTIS IVGVLENLIV LLAVFKNK.. NLQA.....P
MSH QTGARCLEVS ISDGLFLSLG LVSLVENALV VATIAKNR.. NLHS.....P
MC3 SSSAFCEQVF IKPEIFLSLG IVSLLENILV ILAVVRNG.. NLHS.....P
MC4 SDGGCYEQLF VSPEVFVTLG VISLLENILV IVAIAKNK.. NLHS.....P
MC5 NKSSPCEDMG IAVEVFLTLG VISLLENILV IGAIVKNK.. NLHS.....P
melatonin DGARPSWLAS ALACVLIFTI VVDILGNLLV ILSVYRNKKL .......RNA
oxytocin R..RNEALAR VEVAVLCLIL LLALSGNACV LLALRTTRQK .......HSR
conopressinLs FHGVDEDLLK IEIAVQATIL YMTLFGNGIV LLVLRLRRQK .......LTR
V1A RDVRNEELAK LEIAVLAVTF AVAVLGNSSV LLAL...... .HRTPRKTSR
V1B WLGRDEELAK VEIGVLATVL VLATGGNLAV LLTLGQLGRK .......RSR
V2 LDTRDPLLAR AELALLSIVF VAVALSNGLV LAALA..... RRGRRGHWAP
CCK_A PRPSKEWQPA VQILLYSLIF LLSVLGNTLV ITVLI..... RNKRM..RTV
CCK_B GAGTRELELA IRITLYAVIF LMSVGGNMLI IVVLGLS... ..RRL..RTV
NPY1 DCHLPLAMIF TLALAYGAVI ILGVSGNLAL IIIIL..... KQKEM..RNV
NTR DVNTDIYSKV LVTAVYLALF VVGTVGNTVT AFTLAR.... KKSLQSLQST
NK1 QFVQPAWQIV LWAAAYTVIV VTSVVGNVVV MWIILA.... .HKRM..RTV
NK2 AFSMPSWQLA LWAPAYLALV LVAVTGNAIV IWIILA.... .HRRM..RTV
NK3 QFVQPSWRIA LWSLAYGVVV AVAVLGNLIV IWIILA.... .HKRM..RTV
blueops YHIAPVWAFY LQAAFMGTVF LIGFPLNAMV LVATL..... RYKKL..RQP
greenops YHIAPRWVYH LTSVWMIFVV IASVFTNGLV LAATM..... KFKKL..RHP
redops YHIAPRWVYH LTSVWMIFVV TASVFTNGLV LAATM..... KFKKL..RHP
rhodopsin YYLAEPWQFS MLAAYMFLLI VLGFPINFLT LYVTVQ.... .HKKL..RTP
violetopsGg YHIAPPWAFY LQTAFMGIVF AVGTPLNAVV LWVTVRYKRL .......RQP
opsin_crab FPPMNPLWYS ILGVAMIILG IICVLGNGMV IYLMMTTKSL .......RTP
ET_Aprec QTKITSAFKY INTVISCTIF IVGMVGNATL LRIIYQ.... .NKCM..RNG
ET_Bprec PIEIKETFKY INTVVSCLVF VLGIIGNSTL LRIIYKNK.. ...CM..RNG
ET_Cfrog RAKIRHAFKY VTTILSCVIF LVGIVGNSTL LRIIYKNK.. ...CM..RNG
galanin PLFGIGVENF VTLVVFGLIF ALGVLGNSLV ITVLARSK.. ...PGKPRST
NMB GTTTELVIRC VIPSLYLLII TVGLLGNIML VKIFITNS.. ...AM..RSV
GRP DDWSHPGILY VIPAVYGVII LIGLIGNITL IKIFCTVK.. ...SM..RNV
BRS3 DNSPGIEALC AIYITYAVII SVGILGNAIL IKVFFKTK.. ...SM..QTV
deltaOP GSASSLALAI AITALYSAVC AVGLLGNVLV MFGIVRYT.. ...KM..KTA
kappaOP PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYT.. ...KM..KTA
muOP GSP.SMITAI TIMALYSIVC VVGLFGNFLV MYVIVRYT.. ...KM..KTA
OPRX GAFLPLGLKV TIVGLYLAVC VGGLLGNCLV MYVILRHT.. ...KM..KTA
CB1 FMVLNPSQQL AIAVLSLTLG TFTVLENLLV LCVILHSR.. SLRCR....P
CB2 YMILSGPQKT AVAVLCTLLG LLSALENVAV LYLILSSH.. QLRRK....P
SSTR1 TLSEGQGSAI LISFIYSVVC LVGLCGNSMV IYVILRYA.. ...KM..KTA
SSTR2 EPYYDLTSNA VLTFIYFVVC IIGLCGNTLV IYVILRYA.. ...KM..KTI
SSTR3 SPAGLAVSGV LIPLVYLVVC VVGLLGNSLV IYVVLRHT.. ...AS..PSV
SSTR4 GDARAAG.MV AIQCIYALVC LVGLVGNALV IFVILRYA.. ...KM..KTA
SSTR5 PAPSAGARAV LVPVLYLLVC AAGLGGNTLV IYVVLRFA.. ...KM..KTV
IL8A MLETETLNKY VVIIAYALVF LLSLLGNSLV MLVILYSR.. ...VG..RSV
IL8B EPESLEINKY FVVIIYALVF LLSLLGNSLV MLVILYSR.. ...VG..RSV
AT1a KAGRHNYIFV MIPTLYSIIF VVGIFGNSLV VIVIYFYM.. ...KL..KTV
AT1brat KAGRHNYIFV MIPTLYSIIF VVGIFGNSLV VIVIYFYM.. ...KL..KTV
AT2 QKPSDKH.LD AIPILYYIIF VIGFLVNIVV VTLFCCQK.. ...GP..KKV
BK1 APEAWDLLHR VLPTFIISIC FFGLLGNLFV LLVFLLPR.. .....RQLNV
BK2 QVEWLGWLNT IQPPFLWVLF VLATLENIFV LSVFCLHK.. .....SSCTV
P2Y7 PSLGVEFISL LAIILLSVAL AVGLPGNSFV VWSILKRMQ. ......KRSV
P2Y6 CVYREDFKRL LLPPVYSVVL VVGLPLNVCV IAQICASRR. ......TLTR
P2Y5 CSTEDSFKYT LYGCVFSMVF VLGLIANCVA IYIFTFTLK. ......VRNE
P2Y4 CWFDEDFKFI LLPVSYAVVF VLGLGLNAPT LWLFIFRLR. ......PWDA
P2Y3chick CTFHEEFKQV LLPLVYSVVF LLGLPLNAVV IGQIWLARK. ......ALTR
P2Y2 CRFNEDFKYV LLPVSYGVVC VLGLCLNAVG LYIFLCRLK. ......TWNA
P2Y1 ALTKTGFQFY YLPAVYILVF IIGFLGNSVA IWMFVFHMK. ......PWSG
THRprec GYLTSSWLTL FVPSVYTGVF VVSLPLNIMA IVVFILKM.. ...KV..KKP
C5a TSNTLRVPDI LALVIFAVVF LVGVLGNALV VWVTAFEA.. ...K...RTI
GP01mouse AESEPELVVN PWDIVLCSSG TLICCENAVV VLIIF.HSPS LR......AP
R334rat VESEPELVVN PWDIVLCSSG TLICCENAVV VLIIF.HSPS LR......AP
GP21mouse GPATLLPSPR AWDVVLCISG TLVSCENALV VAIIV.GTPA FR......AP
GCRCmouse AESQNPTVKA LLIVAYSFTI VFSLFGNVLV CHVIFK.NQR ......MHSA
TXKR ...QPPWAVA LWSLAYGAVV AVAVLGNLVV IWIVLA.HKR MR......TV
G10Drat MELNENTKQV VLFVFYLAIF VVGLVENVLV IC.VNCRRSG R......VGM
RDC1 NMPNKSVLLY TLSFIYIFIF VIGMIANSVV VW.VNIQAKT TGYDT.....
BLR1 ...MASFKAV FVPVAYSLIF LLGVIGNVLV LV.ILERHRQ TRSSTE....
CL5 REENANFNKI FLPTIYSIIF LTGIVGNGLV IL.VMGYQKK LRSMTDKYR.
LCR1 REENANFNKI FLPTIYSIIF LTGIVGNGLV IL.VMGYQKK LRSMTDKYR.
EBI1 KKDVRNFKAW FLPIMYSIIC FVGLLGNGLV VL.TYIYFKR LKTMTDTY..
RBS1rat LGDIVAFGTI FLSIFYSLVF TFGLVGNLLV VL.ALTNSRK SKSITDIY..
EBI2 LYAHHSTARI VMPLHYSLVF IIGLVGNLLA LV.VIVQNRK KINSTTLY..
GCRTchick CSTEDSFKYT LYGCVFSMVF VLGLIANCVA IY.IFTFTLK VRNETTTY..
APJ EYTDWKSSGA LIPAIYMLVF LLGTTGNGLV LWTVFRSSRE KRRSAD....
RTArat EQIATLPPPA VTNYIFLLLC LCGLVGNGLV LWFFGFSIK. .RT......P
UHRrat SLQLVHQLKG LIVMLYSIVV VVGLVGNCLL VLVIARVR.. .....RLHNV
FMRL1 EPAGHTVLWI FSLLVHGVTF VFGVLGNGLV IWVA.GFR.. .....MTRTV
FMRL2 ESAGYTVLRI LPLVVLGVTF VLGVLGNGLV IWVA.GFR.. .....MTRTV
fMLP VSAGYLFLDI ITYLVFAVTF VLGVLGNGLV IWVA.GFR.. .....MTHTV
OLF1catfish NGFYNIPHTK YYYAFLCIAY AVTVLGNSFI MCTIYLAR.. .....SLHTA
OLF3catfish TGLYNIPHAK YYYLFLCFVY TVTFLGNSFI MGTIYLAR.. .....SLHTA
OLF8catfish GFHDLGEWGP ILSIPYLLMF LLSSTSNLTL IYLIISQR.. .....ALHSP
OLF32Acatfish SGFSGIPFSQ YYFAFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF32Bcatfish SGFSGIPFSQ YYFVFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF32Ccatfish SGFSGIPFSQ YYFVFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF32Dcatfish SGFSGIPFSQ YYFVFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF47catfish IAYNSLGNKN YLILALGIIY LITLLCNFTL LAIILMNS.. .....SLQNP
OLF202catfish FPGLPPNYYG LVSVVMFFVY VCTLIGNCTF FTLFLREK.. .....SLQKP
OLFCOR1chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IALISVDL.. .....HLQTP
OLFCOR2chicken LTD.NPRLQM PLFMVFLVIY TTTLLTNLGL IALIGMDL.. .....HLQTP
OLFCOR3chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IRLISVDL.. .....HLQTP
OLFCOR4chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IRLISVDL.. .....HLQTP
OLFCOR5chicken LTD.NPRLQM PLFMVFLAIY TITLLANLGL IALISVDF.. .....HLQTP
OLFCOR6chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IALIRIDL.. .....QLQTP
OLFdog LPI.DPDQRD LFYALFLAMY VTTILGNLLI IVLIQLDS.. .....HLHTP
OLF07E MSE.SPEQQQ ILFWMFLSMY LVTVVGNVLI ILAISSDS.. .....RLHTP
OLF07I LPI.QPEQQN LCYALFLAMY LTTLLGNLLI IVLIRLDS.. .....HLHTP
OLF07J FSS.FHEQQI TLFGVFLALY ILTLAGNIII VTIIRIDL.. .....HLHTP
OLFOR3mouse VSD.HPHLEI IFFAVILASY LLTLVGNLTI ILLSRLDA.. .....RLHTP
OLFrat LTK.QPELLL PLFFLFLVIY VLTVVGNLGM ILLIIVSP.. .....LLHTP
OLFF3rat FVE.NKDLQP LIYGLFLSMY LVTVIGNISI IVAIISDP.. .....CLHTP
OLFF5rat LSR.QPQQQQ LLFLLFLIMY LATVLGNLLI ILAIGTDS.. .....RLHTP
OLFF6rat FPG.PRSMRI GLFLLFLVMY LLTVVGNLAI ISLVGAHR.. .....CLQTP
OLFF12rat FTE.NPQLHF LIFALFLSMY LVTVLGNLLI IMAIITQS.. .....HLHTP
OLFI3rat LPI.PEEHQH LFYALFLVMY LTTILGNLLI IVLVQLDS.. .....QLHTP
OLFI7rat FPA.PAPLRV LLFFLSLLXY VLVLTENMLI IIAIRNHP.. .....TLHKP
OLFI8rat LPI.PPEHQQ LFFALFLIMY LTTFLGNLLI VVLVQLDS.. .....HLHTP
OLFI9rat LPF.PPEYQH LFYALFLAMY LTTLLGNLII IILILLDS.. .....HLHTP
OLFI14rat LPI.PSEYHL LFYALFLAMY LTIILGNLLI IVLVRLDS.. .....HLHMP
OLFI15rat LPI.PSEHQH VFYALFLSMY LTTVLGNLII IILIHLDS.. .....HLHTP
OLFOR17_40 LLE.APGLQP VVFVLFLFAY LVTVRGNLSI LAAVLVEP.. .....KLHTP
GUST27rat ....MILNCN PFSGLFLSMY LVTVLGNLLI ILAVSSNSHL .......HNL
RPE PTGFGELEVL AVGMVLLVEA LSGLSLNTLT IFSFCKTPEL .......RTP
HHRF1 FTDVLNQSKP VTLFLYGVVF LFGSIGNFLV IFTITWRRRI .......QCS
HHRF2 NSTEIYQLFE YTRLGVWLMC IVGTFLNVLV ITTILYYRRK K......KSP
HHRF3 MTGPLFAIRT TEAVLNTFII FVGGPLNAIV LITQLLTNRV LG.....YST
MCP-1A ..DVKQIGAQ LLPPLYSLVF IFGFVGNMLV VLILINCKKL .......KCL
MCP-1B ..DVKQIGAQ LLPPLYSLVF IFGFVGNMLV VLILINCKKL .......KCL
PPR1bovine ..EVRKFAKV FLPAFFTIAF IIGLAGNSTV VAIYAYYKKR .......RTK
1111111111 1111111111 1111111111 1111111111 222
2222223333 3333334444 4444445555 5555556666 333
4567890123 4567890123 4567890123 4567890123 678
151 200
GPCRAelegans TRFLMCNLAF ADFILGLYIF ILTSVSAVTR GDYHNYVQQW QNGAGCKILG
GRH .KLLLKHLTL ANLLETLIVM PLDGMWNITV QWYA...... .GELLCKVLS
TRH TNCYLVSLAV ADLMVLVAAG LPNITDSIYG SWVYGYV... ....GCLCIT
FSHprec PRFLMCNLAF ADLCIGIYLL LIASVDIHTK SQYHNYAIDW QTGAGCDAAG
TSHprec PRFLMCNLAF ADFCMGMYLL LIASVDLYTH SEYYNHAIDW QTGPGCNTAG
LH_CGprec PRFLMCNLSF ADFCMGLYLL LIASVDSQTK GQYYNHAIDW QTGSGCSTAG
PGE_EP1 FLLFVASLLA TDLAGHVIPG ALVLRLYTA. .......GRA PAGGACHFLG
PGE_EP2 FYTLVCGLAV TDLLGTLLVS PVTIATYMKG ......QWPG GQP.LCEYST
PGE_EP3 FHVLVTELVF TDLLGTCLIS PVVLASYARN QT..LVALAP ESR.ACTYFA
PGF FLLLASGLVI TDFFGHLING AIAVFVYASD KE..WIRFDQ .SNVLCSIFG
PGI FAVLVTGLAA TDLLGTSFLS PAVFVAYARN SS..LLGLAR GGPALCDAFA
TXA2 FLTFLCGLVL TDFLGLLVTG TIVVSQHAAL FE..WHAVDP GCR.LCRFMG
PAF ..IFMVNLTM ADMLFLITLP LWIVYYQ.NQ GNWIL..... PK.FLCNVAG
M2 NNYFLFSLAC ADLIIGVFSM NLYTLYTVIG ......YWPL .GPVVCDLWL
M4 NNYFLFSLAC ADLIIGAFSM NLYTVYIIKG ......YWPL .GAVVCDLWL
M1 NNYFLLSLAC ADLIIGTFSM NLYTTYLLMG ......HWAL .GTLACDLWL
M3 NNYFLLSLAC ADLIIGVISM NLFTTYIIMN ......RWAL .GNLACDLWL
M5 NNYYLLSLAC ADLIIGIFSM NLYTTYILMG ......RWAL .GSLACDLWL
H1 GNLYIVSLSV ADLIVGAVVM PMNILYLLMS ......KWSL .GRPLCLFWL
H2 TNCFIVSLAI TDLLLGLLVL PFSAIYQLSC ......KWSF G.KVFCNIYT
5HT1A ANYLIGSLAV TDLMVSVLVL PMAALYQVLN ......KWTL .GQVTCDLFI
5HT1B ANYLIASLAV TDLLVSILVM PISTMYTVTG ......RWTL .GQVVCDFWL
5HT1D ANYLIGSLAT TDLLVSILVM PISIAYTITH ......TWNF .GQILCDIWL
5HT1E ANYLICSLAV TDLLVAVLVM PLSIIYIVMD ......RWKL .GYFLCEVWL
5HT1F ANYLICSLAV TDFLVAVLVM PFSIVYIVRE ......SWIM .GQVVCDIWL
5HT2A TNYFLMSLAI ADMLLGFLVM PVSMLTILYG .....YRWPL P.SKLCAVWI
5HT2B TNYFLMSLAV ADLLVGLFVM PIALLTIMFE .....AMWPL P.LVLCPAWL
5HT2C TNYFLMSLAI ADMLVGLLVM PLSLLAILYD .....YVWPL P.RYLCPVWI
5HT5A PHNLVASMAV SDVLVAALVM PLSLVHELS. ....GRRWQL .GRRLCQLWI
5HT5Brat PHNLVASTAV SDVLVAALVM PLSLVSELSA ....GRRWQL .GRSLCHVWI
5HT6rat SNFFLVSLFT SDLMVGLVVM PPAMLNALYG ......RWVL A.RGLCLLWT
5HT7 SNYLIVSLAL ADLSVAVAVM PFVSVTDLIG G.....KWIF .GHFFCNVFI
alpha1A TNYFIVNLAV ADLLLSATVL PFSATMEVLG ......FWAF G.RAFCDVWA
alpha1B TNYFIVNLAM ADLLLSFTVL PFSAALEVLG ......YWVL G.RIFCDIWA
alpha1C THYYIVNLAV ADLLLTSTVL PFSAIFEVLG ......YWAF G.RVFCNIWA
alpha2A QNLFLVSLAS ADILVATLVI PFSLANEVMG .Y.....WYF .GKAWCEIYL
alpha2B QNLFLVSLAA ADILVATLII PFSLANELLG .Y.....WYF R.RTWCEVYL
alpha2C1 QNLFLVSLAS ADILVATLVM PFSLANELMA .Y.....WYF .GQVWCGVYL
alpha2C2 QNLFLVSLAS ADILVATLVM PFSLANELMA .Y.....WYF .GQVWCGVYL
beta1 TNLFIMSLAS ADLVMGLLVV PFGATIVVWG ......RWEY GS.FFCELWT
beta2 TNYFITSLAC ADLVMGLAVV PFGAAHILMK ......MWTF GN.FWCEFWT
beta3 TNVFVTSLAA ADLVMGLLVV PPAATLALTG ......HWPL GA.TGCELWT
beta4turkey TNVFVTSLAC ADLVMGLLVV PPGATILLSG ......HWPY GT.VVCELWT
D1A TNFFVISLAV SDLLVAVLVM PWKAVAEIAG ......FWPF GS..FCNIWV
D2 TNYLIVSLAV ADLLVATLVM PWVVYLEVVG E......WKF S.RIHCDIFV
D3 TNYLVVSLAV ADLLVATLVM PWVVYLEVTG GV.....WNF S.RICCDVFV
D4 TNSFIVSLAA ADLLLALLVL PLFVYSEVQG GA.....WLL SPRLC.DALM
D5 TNVFIVSLAV SDLFVALLVM PWKAVAEVAG ......YWPF GA..FCDVWV
A1 TFCFIVSLAV ADVAVGALVI PLAILINIGP QTYFHTCL.. .......MVA
A2a TNYFVVSLAA ADIAVGVLAI PFAITISTGF CAACHGCL.. .......FIA
A2b TNYFLVSLAA ADVAVGLFAI PFAITISLGF CTDFYGCL.. .......FLA
A3 TFYFIVSLAL ADIAVGVLVM PLAIVVSLGI TIHFYSCL.. .......FMT
OCdrome QNFFIVSLAV ADLTVALLVL PFNVAYSILG R......WEF GI.HLCKLWL
ACTH MYFFICSLAI SDMLGSLYKI LENILIILRN MGYLKPRGSF ET.TADDIID
MSH MYCFICCLAL SDLLVSGTNV LETAVILLLE AGALVARAAV LQ.QLDNVID
MC3 MYFFLCSLAV ADMLVSVSNA LETIMIAIVH SDDYTFEDQF IQ.HMDNIFD
MC4 MYFFICSLAV ADMLVSVSNG SETIIITLLN STD.TDAQSF TV.NIDNVID
MC5 MYFFVCSLAV ADMLVSMSSA WETITIYLLN NKHLVIADAF V.RHIDNVFD
melatonin GNIFVVSLAV ADLVVAIYPY PLVLMSIFNN GWNLGYLH.. .....CQVSG
oxytocin LFFFMKHLSI ADLVVAVFQV LPQLLWDITF RFYGP..... ..DLLCRLVK
conopressinLs MQWFIAHLAF ADIFVGFFNI LPQLISDVTI VFHGDD.... ...FTCRFIK
V1A MHLFIRHLSL ADLAVAFFQV LPQMCWDITY RFRGPD.... ...WLCRVVK
V1B MHLFVLHLAL TDLAVALFQV LPQLLWDITY RFQGP..... ..DLLCRAVK
V2 IHVFIGHLCL ADLAVALFQV LPQLAWKATD RFRGPD.... ...ALCRAVK
CCK_A TNIFLLSLAV SDLMLCLFCM PFNLIPNLLK DFIFGS.... ...AVCKTTT
CCK_B TNAFLLSLAV SDLLLAVACM PFTLLPNLMG TFIFGT.... ...VICKAVS
NPY1 TNILIVNLSF SDLLVAIMCL PFTFVYTLMD HWVFGE.... ...AMCKLNP
NTR VHYHLGSLAL SDLLTLLLAM PVELYNFIWV HHPWAF.... .GDAGCRGYY
NK1 TNYFLVNLAF AEASMAAFNT VVNFTYAVHN EWYYGL.... ...FYCKFHN
NK2 TNYFIVNLAL ADLCMAAFNA AFNFVYASHN IWYFGR.... ...AFCYFQN
NK3 TNYFLVNLAF SDASMAAFNT LVNFIYALHS EWYFGA.... ...NYCRFQN
blueops LNYILVNVSF GGFLLCIFSV FPVFVASCNG YFVFGR.... ...HVCALEG
greenops LNWILVNLAV ADLAETVIAS TISVVNQVYG YFVLGH.... ...PMCVLEG
redops LNWILVNLAV ADLAETVIAS TISIVNQVSG YFVLGH.... ...PMCVLEG
rhodopsin LNYILLNLAV ADLFMVLGGF TSTLYTSLHG YFVFGP.... ...TGCNLEG
violetopsGg LNYILVNISA SGFVSCVLSV FVVFVASARG YFVFG..... ..KRVCELEA
opsin_crab TNLLVVNLAF SDFCMMAFMM PTMTSNCFAE TWILG..... ..PFMCEVYG
ET_Aprec PNALIASLAL GDLIYVVIDL PINVFKLLAG RWPFDH.NDF GV.FLCKLFP
ET_Bprec PNILIASLAL GDLLHIVIDI PINVYKLLAE DWPFGAE... ....MCKLVP
ET_Cfrog PNVLIASLAL GDLFYILIAI PIISISFWLS TGH....... ....SEYIYQ
galanin TNLFILNLSI ADLAYLLFCI PFQATVYALP TWVLGA.... ...FICKFIH
NMB PNIFISNLAA GDLLLLLTCV PVDASRYFFD EWMFGKVG.. .....CKLIP
GRP PNLFISSLAL GDLLLLITCA PVDASRYLAD RWLFGRIG.. .....CKLIP
BRS3 PNIFITSLAF GDLLLLLTCV PVDATHYLAE GWLFGRIG.. .....CKVLS
deltaOP TNIYIFNLAL ADALATSTLP FQSAKYLMET .WPFGE.... ...LLCKAVL
kappaOP TNIYIFNLAL ADALVTTTMP FQSTVYLMNS .WPFGD.... ...VLCKIVI
muOP TNIYIFNLAL ADALATSTLP FQSVNYLMGT .WPFGT.... ...ILCKIVI
OPRX TNIYIFNLAL ADTLVLLTLP FQGTDILLGF .WPFGN.... ...ALCKTVI
CB1 SYHFIGSLAV ADLLGSVIFV YSFIDFHVFH RKD....... .SRNVFLFKL
CB2 SYLFIGSLAG ADFLASVVFA CSFVNFHVFH GVD....... .SKAVFLLKI
SSTR1 TNIYILNLAI ADELLMLSVP FLVTSTLLRH .WPFGA.... ...LLCRLVL
SSTR2 TNIYILNLAI ADELFMLGLP FLAMQVALVH .WPFGK.... ...AICRVVM
SSTR3 TNVYILNLAL ADELFMLGLP FLAAQNALSY .WPFGS.... ...LMCRLVM
SSTR4 TNIYLLNLAV ADELFMLSVP FVASSAALRH .WPFGS.... ...VLCRAVL
SSTR5 TNIYILNLAV ADVLYMLGLP FLATQNAASF .WPFGP.... ...VLCRLVM
IL8A TDVYLLNLAL ADLLFALTLP IWAA..SKVN GWIFGT.... ...FLCKVVS
IL8B TDVYLLNLAL ADLLFALTLP IWAA..SKVN GWIFGT.... ...FLCKVVS
AT1a ASVFLLNLAL ADLCFLLTLP LWAVYTAMEY RWPFGN.... ...YLCKIAS
AT1brat ASVFLLNLAL ADLCFLLTLP LWAVYTAMEY RWPFGN.... ...HLCKIAS
AT2 SSIYIFNLAV ADLLLLATLP LWATYYSYRY DWLFGP.... ...VMCKVFG
BK1 AEIYLANLAA SDLVFVLGLP FWAENIWNQF NWPFGA.... ...LLCRVIN
BK2 AEIYLGNLAA ADLILACGLP FWAITISNNF DWLFGE.... ...TLCRVVN
P2Y7 TALMVLNLAL ADLAVLLTAP FFLHFLAQGT WSFGLA.... ....GCRLCH
P2Y6 SAVYTLNLAL ADLLYACSLP LLIYNYARGD HWPFGD.... ...LACRLVR
P2Y5 TTTYMLNLAI SDLLFVFTLP FRIYYFVVRN .WPFGD.... ...VLCKISV
P2Y4 TATYMFHLAL SDTLYVVSLP TLIYYYAAHN HWPFGT.... ...EICKFVR
P2Y3chick TTIYMLNLAM ADLLYVCSLP LLIYNYTQKD YWPFGD.... ...FTCKFVR
P2Y2 STTYMFHLAV SDALYAASLP LLVYYYARGD HWPFST.... ...VLCKLVR
P2Y1 ISVYMFNLAL ADFLYVLTLP ALIFYYFNKT DWIFGD.... ...AMCKLQR
THRprec AVVYMLHLAT ADVLFVSVLP FKISYYFSGS DWQFGS.... ...ELCRFVT
C5a NAIWFLNLAV ADFLSCLALP ILFTSIVQHH WPFGGA.... ....ACSILP
GP01mouse MFLLIGSLAL ADLLAGLGLI INFVFAYLLQ ....SE.... ...ATKLVTI
R334rat MFLLIGSLAL ADLLAGLGLI INFVFAYLLQ ....SE.... ...ATKLVTI
GP21mouse MFLLVGSLAV ADLLAGLGLV LHFAADFCIG ....SP.... ...EMSLMLV
GCRCmouse TSLFIVNLAV ADIMITLLNT PFTLVRFVNS TWVFGK.... ...GMCHVSR
TXKR TNSFLVNLAF ADAAMAALNA LVNFIYALHG EWYFGA.... ...NYCRFQN
G10Drat LNLYILNMAV ADLGIILSLP VWMLEVMLEY TWLWGS.... ...FSCRFIH
RDC1 .HCYILNLAI ADLWVVLTIP VWVVSLVQHN QWPMGE.... ...LTCKVTH
BLR1 ..TFLFHLAV ADLLLVFILP FAVAEGSV.. GWVLGT.... ...FLCKTVI
CL5 .....LHLSV ADLLFVITLP FWAVDAVA.. NWYFGN.... ...FLCKAVH
LCR1 .....LHLSV ADLLFVITLP FWAVDAVA.. NWYFGN.... ...FLCKAVH
EBI1 ....LLNLAV ADILFLLTLP FWAYSAAK.. SWVFGV.... ...HFCKLIF
RBS1rat ....LLNLAL SDLLFVATLP FWTHYLIS.. HEGLHN.... ...AMCKLTT
EBI2 ....STNLVI SDILFTTALP TRIAYYAMGF DWRIGD.... ...ALCRITA
GCRTchick ....MLNLAI SDLLFVFTLP FRIYYFVVR. NWPFGD.... ...VLCKISV
APJ ..IFIASLAV ADLTFVVTLP LWATYTYRDY DWPFGT.... ...FFCKLSS
RTArat FSIYFLHLAS ADGIYLFSKA VIALLNMGTF LGSFPD.... ...YVRRVSR
UHRrat TNFLIGNLAL SDVLMCAACV PLTLAYAFEP RGWVFG.... ..GGLCHLVF
FMRL1 NTICYLNLAL ADFSFSAILP FRMVSVAMRE KWPFAS.... ...FLCKLVH
FMRL2 TTICYLNLAL ADFSFTATLP FLIVSMAMGE KWPFGW.... ...FLCKLIH
fMLP TTISYLNLAV ADFCFTSTLP FFMVRKAMGG HWPFGW.... ...FLCKFLF
OLF1catfish KYITVFNLAL SDLGGSSALI PKLIDTFLF. ......ENQV ISYEACLANM
OLF3catfish KYIAVFNLAL SDLCGSSALI PKLLDMLLF. ......ENQS ISYEACLSNM
OLF8catfish MCILIGLMAV VDLSMPIFCV PNMLLSFLF. ......NWKG ISLVGCLVQM
OLF32Acatfish KYMGIFNLAL SDFGETNVLI PSLVKTLFF. ......DSQY ISYDACLANM
OLF32Bcatfish KYMGIFNLAL SDFGETNALI PSLVKTLFF. ......DSQY ISYDACLANM
OLF32Ccatfish KYMGIFNLAL SDIGETNALI PSLVKTLFF. ......DSQY ISYDACLTNM
OLF32Dcatfish KYMGIFNLAL SDFGETNALI PSLVKTLFF. ......DSQY ISYDACLANM
OLF47catfish KFLAVFNLAV VDISINSVII PQMVPVFVF. ......NLNH ISFESCFSQM
OLF202catfish MYYIMLNLAA SDVLFSTTTL PKIIARYWF. ......GDGS ISFVGCFIQM
OLFCOR1chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERKT ISYVGCILQY
OLFCOR2chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERRT ISYVGCILQY
OLFCOR3chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERKT ISYVGCILQY
OLFCOR4chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERKT ISYVGCILQY
OLFCOR5chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERRT ISYVGCILQY
OLFCOR6chicken MYIFLQNLSF TDAVYSTVIT PKMLATFL.. .....EETKT ISYVGCILQY
OLFdog MYLFLSNLSF SDLCFSSVTM PKLLQNMQ.. .....SQVPS IPYAGCLTQM
OLF07E VYFFLANLSF TDLFFVTNTI PKMLVNLQ.. .....SHNKA ISYAGCLTQL
OLF07I MYLFLSNLSF SDLCFSSVTI PKLLQNMQ.. .....NQDPS IPYADCLTQM
OLF07J MYFFLSMLST SETVYTLVIL PRMLSSLV.. .....GMSQP MSLAGCATQM
OLFOR3mouse MYFFLSNLSS LDLAFTTSSV PQMLKNLW.. .....GPDKT ISYGGCVTQL
OLFrat MYYFLSSLSF VDLCYSTVIT PKMLVNFL.. .....GKKNF ITYSECMAQF
OLFF3rat MYFFLSNLSF VDICFISTTV PKMLVNIQ.. .....TQNNV ITYAGCITQI
OLFF5rat MYFFLSNLSF VDVCFSSTTV PKVLANHI.. .....LGSQA ISFSGCLTQL
OLFF6rat MYFFLCNLSF LEIWFTTACV PKTLATF... ....APRGGV ISLAGCATQM
OLFF12rat MYFFLANLSF VDICFTSTTI PKMLVNIY.. .....TQSKS ITYEDCISQM
OLFI3rat MYLFLSNLSF SDLCFSSVTM PKLLQNMR.. .....SQDTS IPYGGCLAQT
OLFI7rat MYFFLANMSF LEIWYVTVTI PKMLAGFIG. ..SKENHGQL ISFEACMTQL
OLFI8rat MYLFLSNLSF SDLCFSSVTM LKLLQNIQ.. .....SQVPS ISYAGCLTQI
OLFI9rat MYLFLSNLSF ADLCFSSVTM PKLLQNMQ.. .....SQVPS IPYAGCLAQI
OLFI14rat MYLFLSNLSF SDLCFSSVTM PKLLQNMQ.. .....SQVPS ISYTGCLTQL
OLFI15rat MYLFLSNLSF SDLCFSSVTM PKLLQNMQ.. .....SQVPS IPFAGCLTQL
OLFOR17_40 MYFFLGNLSV LDVGCISVTV PSMLSRLL.. .....SRKRA VPCGACLTQL
GUST27rat MYFFLSNLSF VDICFISTTI PKMLVNIH.. .....SQTKD ISYIECLSQV
RPE CHLLVLSLAL ADSGISLNAL VAATSSLLRR WPYG...... ..SDGCQAHG
HHRF1 GDVYFINLAA ADLLFVCTLP LWMQYLLDHN SLA....... ..SVPCTLLT
HHRF2 SDTYICNLAV ADLLIVVGLP FFLEYAKHHP KLSR...... ..EVVCSGLN
HHRF3 PTIYMTNLYS TNFLTLTVLP FIVLSNQWLL PAG....... ..VASCKFLS
MCP-1A TDIYLLNLAI SDLLFLITLP LWAHSAANEW VFG....... ..NAMCKLFT
MCP-1B TDIYLLNLAI SDLLFLITLP LWAHSAANEW VFG....... ..NAMCKLFT
PPR1bovine TDVYILNLAV ADLFLLFTLP FWAVNAVHGW VLG....... ..KIMCKVTS
2222222222 2222222222 2222222222 3333333
3444444444 4555555555 5666666666 2222222
9012345678 9012345678 9012345678 3456789
201 250
GPCRAelegans FLAVFSSELS LFTLVMMTIE RFYAIVHAMH M.....NARL SFRKTVRFMI
GRH YLKLFSMYAP AFMMVVISLD RSLAITRPLA L..KSNSKVG .....QSMVG
TRH YLQYLGINAS SCSITAFTIE RYIAICHPIK .A....QFLC TFSRAKKIII
FSHprec FFTVFASELS VYTLTAITLE RWHTITHAMQ L....DCKVQ LR.HAASVMV
TSHprec FFTVFASELS VYTLTVITLE RWYAITFAMR L....DRKIR LR.HACAIMV
LH_CGprec FFTVFASELS VYTLTVITLE RWHTITYAIH L....DQKLR LR.HAILIML
PGE_EP1 GCMVFFGLCP LLLGCGMAVE RCVGVTRPLL HAARVSVARA R....L.ALA
PGE_EP2 FILLFFSLSG LSIICAMSVE RYLAINHAYF YSHYVDKR.. ..LAGL.TLF
PGE_EP3 FAMTFFSLAT MLMLFAMALE RYLSIGHPYF ...YQRRVSA ..SGGLAVLP
PGF ICMVFSGLCP LLLGSVMAIE RCIGVTKPIF HSTKITSKHV K....M.MLS
PGI FAMTFFGLAS MLILFAMAVE RCLALSHPYL YAQLDGPRCA R.....LALP
TXA2 VVMIFFGLSP LLLGAAMASE RYLGITRPFS RPAVASQRR. ...AWA.TVG
PAF CLFFINTYCS VAFLGVITYN RFQAVTRPIK TAQANTRKR. ...GIS.LSL
M2 ALDYVVSNAS VMNLLIISFD RYFCVTKPLT Y...PVKRTT .KMAGM.MIA
M4 ALDYVVSNAS VMNLLIISFD RYFCVTKPLT Y...PARRTT .KMAGL.MIA
M1 ALDYVASNAS VMNLLLISFD RYFSVTRPLS Y...RAKRTP .RRAAL.MIG
M3 AIDYVASNAS VMNLLVISFD RYFSITRPLT Y...RAKRTT .KRAGV.MIG
M5 ALDYVASNAS VMNLLVISFD RYFSITRPLT Y...RAKRTP .KRAGI.MIG
H1 SMDYVASTAS IFSVFILCID RYRSVQQPLR Y...LKYRTK .TRASA.TIL
H2 SLDVMLCTAS ILNLFMISLD RYCAVMDPLR Y...PVLVTP VR.VAI.SLV
5HT1A ALDVLCCTSS ILHLCAIALD RYWAITDPID Y...VNKRT. PRRAAA.LIS
5HT1B SSDITCCTAS ILHLCVIALD RYWAITDAVE Y...SAKRT. PKRAAV.MIA
5HT1D SSDITCCTAS ILHLCVIALD RYWAITDALE Y...SKRRT. AGHAAT.MIA
5HT1E SVDMTCCTCS ILHLCVIALD RYWAITNAIE Y...ARKRT. AKRAAL.MIL
5HT1F SVDITCCTCS ILHLSAIALD RYRAITDAVE Y...ARKRT. PKHAGI.MIT
5HT2A YLDVLFSTAS IMHLCAISLD RYVAIQNPIH H.SRFNSRTK .AFLK...II
5HT2B FLDVLFSTAS IMHLCAISVD RYIAIKKPIQ A.NQYNSRAT .AFIK...IT
5HT2C SLDVLFSTAS IMHLCAISLD RYVAIRNPIE H.SRFNSRTK .AIMK...IA
5HT5A ACDVLCCTAS IWNVTAIALD RYWSITRHME Y...TLRTR. KCVSNV.MIA
5HT5Brat SFDVLCCTAS IWNVAAIALD RYWTITRHLQ Y...TLRTR. RRASAL.MIA
5HT6rat AFDVMCCSAS ILNLCLISLD RYLLILSPLR Y...KLRMTA PR.ALA.LIL
5HT7 AMDVMCCTAS IMTLCVISID RYLGITRPLT Y...PVRQN. GKCMAK.MIL
alpha1A AVDVLCCTAS ILSLCTISVD RYVGVRHSLK Y...PAIMTE RK.AAA.ILA
alpha1B AVDVLCCTAS ILSLCAISID RYIGVRYSLQ Y...PTLVTR RK.AIL.ALL
alpha1C AVDVLCCTAS IMGLCIISID RYIGVTYPLR Y...PTIVTQ RR.GLM.ALL
alpha2A ALDVLFCTSS IVHLCAISLD RYWSITQAIE Y...NLKRT. PRRIKA.III
alpha2B ALDVLFCTSS IVHLCAISLD RYWAVSRALE Y...NSKRT. PRRIKC.IIL
alpha2C1 ALDVLFCTSS IVHLCAISLD RYWSVTQAVE Y...NLKRT. PRRVKA.TIV
alpha2C2 ALDVLFCTSS IVHLCAISLD RYWSVTQAVE Y...NLKRT. PRRVKA.TIV
beta1 SVDVLCVTAS IETLCVIALD RYLAITSPFR Y...QSLLTR AR.ARG.LVC
beta2 SIDVLCVTAS IETLCVIAVD RYFAITSPFK Y...QSLLTK NK.ARV.IIL
beta3 SVDVLCVTAS IETLCALAVD RYLAVTNPLR Y...GALVTK RC.ART.AVV
beta4turkey SLDVLCVTAS IETLCAIAVD RYLAITAPLQ Y...EALVTK GRA..WAVVC
D1A AFDIMCSTAS ILNLCVISVD RYWAISSPFR Y...ERK.MT PKAAFI.LIS
D2 TLDVMMCTAS ILNLCAISID RYTAVAMPML Y..NTRY.SS KRRVTV.MIS
D3 TLDVMMCTAS ILNLCAISID RYTAVVMPVH YQHGTGQ.SS CRRVAL.MIT
D4 AMDVMLCTAS IFNLCAISVD RFVAVAVPLR Y...NRQ.GG SRRQLL.LIG
D5 AFDIMCSTAS ILNLCVISVD RYWAISRPFR Y...KRK.MT QRMALV.MVG
A1 CPVLILTQSS ILALLAIAVD RYLRVKIPLR Y..KMVVTPR R...AAVAIA
A2a CFVLVLTQSS IFSLLAIAID RYIAIRIPLR Y..NGLVTGT RAK...GIIA
A2b CFVLVLTQSS IFSLLAVAVD RYLAICVPLR Y..KSLVTGT RAR...GVIA
A3 CLLLIFTHAS IMSLLAIAVD RYLRVKLTVR Y..KRVTTHR R...IWLALG
OCdrome TCDVLCCTSS ILNLCAIALD RYWAITDPIN Y.AQKR...T VGR.VLLLIS
ACTH SLFVLSLLGS IFSLSVIAAD RYITIFHALR Y..HSIVTMR R...TVVVLT
MSH VITCSSMLSS LCFLGAIAVD RYISIFYALR Y..HSIVTLP RAPR...AVA
MC3 SMICISLVAS ICNLLAIAVD RYVTIFYALR Y..HSIMTVR K...ALTLIV
MC4 SVICSSLLAS ICSLLSIAVD RYFTIFYALQ Y..HNIMTVK RV...GIIIS
MC5 SMICISVVAS MCSLLAIAVD RYVTIFYALR Y..HHIMTAR RS...GAIIA
melatonin FLMGLSVIGS IFNITGIAIN RYCYICHSLK YDKL.....Y SSKNSLCYVL
oxytocin YLQVVGMFAS TYLLLLMSLD RCLAICQPLR SLRR...... RTDR..LAVL
conopressinLs YFQVIAMYAS SYVLVMAAID RYLSICHPLT SQTL..SPKR ....VHLMIA
V1A HLQVFGMFAS AYMLVVMTAD RYIAVCHPLK T..LQQ.PAR R...SRLMIA
V1B YLQVLSMFAS TYMLLAMTLD RYLAVCHPLR SLQQ...... PGQSTYLLIA
V2 YLQMVGMYAS SYMILAMTLD RHRAICRPML A..YRHG..S .GAHWNRPVL
CCK_A YFMGTSVSVS TFNLVAISLE RYGAICKPLQ S..RVWQTKS ...HALKVIA
CCK_B YLMGVSVSVS TLSLVAIALE RYSAICRPLQ A..RVWQTRS ...HAARVIV
NPY1 FVQCVSITVS IFSLVLIAVE RHQLIINPRG W..RP..... NNRHAYVGIA
NTR FLRDACTYAT ALNVASLSVE RYLAICHPFK AKTLMSRS.. ...RTKKFIS
NK1 FFPIAAVFAS IYSMTAVAFD RYMAIIHPL. ...QPRLS.. .ATATKVVIC
NK2 LFPITAMFVS IYSMTAIAAD RYMAIVHPF. ...QPRLS.. .APSTKAVIA
NK3 FFPITAVFAS IYSMTAIAVD RYMAIIDPL. ...KPRLS.. .ATATKIVIG
blueops FLGTVAGLVT GWSLAFLAFE RYIVICKPF. G..NFRF... SSKHALTVVL
greenops YTVSLCGITG LWSLAIISWE RWMVVCKPF. G..NVRF... DAKLAIVGIA
redops YTVSLCGITG LWSLAIISWE RWLVVCKPF. G..NVRF... DAKLAIVGIA
rhodopsin FFATLGGEIA LWSLVVLAIE RYVVVCKPM. S..NFRF... GENHAIMGVA
violetopsGg FVGTHGGLVT GWSLAFLAFE RYIVICKPFG NFRF...... SSRHALLVVV
opsin_crab MAGSLFGCAS IWSMVMITLD RYNVIVRGMA AAPL...... THKKATLLLL
ET_Aprec FLQKSSVGIT VLNLCALSVD RYRAVASWSR V..Q...GIG IPLVTAIEIV
ET_Bprec FIQKASVGIT VLSLCALSID RYRAVASWSR I..K...GIG VPKWTAVEIV
ET_Cfrog LVHLYRARVY SLSLCALSID RYRAVASWNR I..R...SIG IPVRKAIELT
galanin YFFTVSMLVS IFTLAAMSVD RYVAIVHSRR S.....SSLR VSRNALLGVG
NMB VIQLTSVGVS VFTLTALSAD RYRAIVNPMD M..Q...TSG ALLRTCVKAM
GRP FIQLTSVGVS VFTLTALSAD RYKAIVRPMD I..Q...ASH ALMKICLKAA
BRS3 FIRLTSVGVS VFTLTILSAD RYKAVVKPLE R..Q...PSN AILKTCVKAG
deltaOP SIDYYNMFTS IFTLTMMSVD RYIAVCHPVK A..LDFRTPA KAK...LINI
kappaOP SIDYYNMFTS IFTLTMMSVD RYIAVCHPVK A..LDFRTPL KAK...IINI
muOP SIDYYNMFTS IFTLCTMSVD RYIAVCHPVK A..LDFRTPR NAK...IINV
OPRX AIDYYNMFTS TFTLTAMSVD RYVAICHPIR A..LDVRT.. SSK.AQAVNV
CB1 GGVTASFTAS VGSLFLTAID RYISIHRPLA Y..KRIVTRP ..K.AVVAFC
CB2 GSVTMTFTAS VGSLLLTAID RYLCLRYPPS Y..KALLTRG ..R.ALVTLG
SSTR1 SVDAVNMFTS IYCLTVLSVD RYVAVVHPIK A..ARYRRPT VAK...VVNL
SSTR2 TVDGINQFTS IFCLTVMSID RYLAVVHPIK S..AKWRRPR TAK...MITM
SSTR3 AVDGINQFTS IFCLTVMSVD RYLAVVHPTR S..ARWRTAP VAR...TVSA
SSTR4 SVDGLNMFTS VFCLTVLSVD RYVAVVHPLR A..ATYRRPS VAK...LINL
SSTR5 TLDGVNQFTS VFCLTVMSVD RYLAVVHPLS S..ARWRRPR VAK...LASA
IL8A LLKEVNFYSG ILLLACISVD RYLAIVHATR T...LTQKRH LVK...FVCL
IL8B LLKEVNFYSG ILLLACISVD RYLAIVHATR T...LTQKRY LVK...FICL
AT1a ASVSFNLYAS VFLLTCLSID RYLAIVHPMK S..RLRRTML VAK...VTCI
AT1brat ASVSFNLYAS VFLLTCLSID RYLAIVHPMK S..RLRRTML VAK...VTCI
AT2 SFLTLNMFAS IFFITCMSVD RYQSVIYPFL S..Q.RRNPW ...QASYIVP
BK1 GVIKANLFIS IFLVVAISQD RYRVLVHPMA S..GRQQRRR QAR...VTCV
BK2 AIISMNLYSS ICFLMLVSID RYLALVKTMS M..GRMRGVR WAK...LYSL
P2Y7 YVCGVSMYAS VLLITAMSLD RSLAVARPFV SQKLRTKAMA RR.....VLA
P2Y6 FLFYANLHGS ILFLTCISFQ RYLGICHPLA PWHKRGGRRA AW....VVCG
P2Y5 TLFYTNMYGS ILFLTCISVD RFLAIVHPFR SKTLRTK.RN AR....IVCV
P2Y4 FLFYWNLYCS VLFLTCISVH RYLGICHPLR AL.RWGRPRL AG....LLCL
P2Y3chick FQFYTNLHGS ILFLTCISVQ RYMGICHPLA SWHKKKGKKL TW....LVCA
P2Y2 FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SL.RWGRARY AR....RVAG
P2Y1 FIFHVNLYGS ILFLTCISAH RYSGVVYPLK SLG.RLKKKN AI....CISV
THRprec AAFYCNMYAS ILLMTVISID RFLAVVYPMQ S..LSWR... TLGRASFTCL
C5a SLILLNMYAS ILLLATISAD RFLLVFKPIW CQNFR..... GAGLAWIACA
GP01mouse GLIVASFSAS VCSLLAITVD RYLSLYYALT YHSERT.... .VTFTYVMLV
R334rat GLIVASFSAS VCSLLAITVD RYLSLYYALT YHSERT.... .VTFTYVMLV
GP21mouse GVLAMAFTAS IGSLLAITVD RYLSLYNALT YYSETT.... .VTRTYVMLA
GCRCmouse FAQYCSLHVS ALTLTAIAVD RHQVIMHPLK P....RIS.. .ITKGVIYIA
TXKR FFPITAVFAS IYSMTAIAVD RYMAIIDPLK P....RLS.. .ATATRIVIG
G10Drat YFYLANMYSS IFFLTCLSID RYVTLTNTSP SWQRHQHRI. ..RR.AV.CA
RDC1 LIFSINLFSG IFFLTCMSVD RYLSITYFTN TPSSRKKMV. ..RR.VV.CI
BLR1 ALHKVNFYCS SLLLACIAVD RYLAIVHAVH AY..RHRRLL SIHIT...CG
CL5 VIYTVNLYSS VLILAFISLD RYLAIVHA.. TNSQRPRKLL AEK...VVYV
LCR1 VIYTVNLYSS VLILAFISLD RYLAIVHA.. TNSQRPRKLL AEK...VVYV
EBI1 AIYKMSFFSG MLLLLCISID RYVAIVQAVS AHRHRARVLL ISK...LSCV
RBS1rat AFFFIGFFGG IFFITVISID RYLAIVLA.. ANSMNNRTVQ .HGVT..ISL
EBI2 LVFYINTYAG VNFMTCLSID RFIAVVHPLR YNKIKRIE.. HAK...GVCI
GCRTchick TLFYTNMYGS ILFLTCISVD RFLAIVHPFR SKTLRTKR.. NAR...IVCV
APJ YLIFVNMYAS VFCLTGLSFD RYLAIVRPVA NARLRLR... .VS.GAVATA
RTArat IVGLCTFFAG VSLLPAISIE RCVSVIFPMW YWRRRPKR.. .LSAG..VCA
UHRrat FLQPVTVYVS VFTLTTIAVD RYVVLVHPL. ......RRRI SLKLSAYAVL
FMRL1 VMIDINLFVS VYLITIIALD RCICVLHPAW AQNHR..... TMSLAKRVMT
FMRL2 IVVDINLFGS VFLIGFIALD RCICVLHPVW AQNHR..... TVSLAMKVIV
fMLP TIVDINLFGS VFLIALIALD RCVCVLHPVW TQNHR..... TVSLAKKVII
OLF1catfish FFVLFFMTVQ SLTLLVMAYD RVVAICFPLR YNVIV..... TKEAMTLIIV
OLF3catfish FFVYCFMTLQ CLTLLALAYD RLIAICYPLR YHAIV..... TKAAMIFIIG
OLF8catfish FCIHCAGTFQ STILLWMALD RFFAICRPLY YQKYM..... GMPNFLKFII
OLF32Acatfish FLTFFFSSGQ ALTLVALAYD RFIAICLPLR YNAIV..... NNSFMFASLT
OLF32Bcatfish FFTFLFFGGQ ALTLVALAYD RFIAICLPLR YHAIV..... NNSFMFATLT
OLF32Ccatfish FFTFFFSGGQ ALTLVALAYD RFIAICLPLR YHAIV..... NNSFMFATLT
OLF32Dcatfish FFTFFFAGGQ ALTLVALAYD RFIAICLPLR YHAIV..... NNSFMFVTLI
OLF47catfish FFMHFFGDME SFSLALLAYD RLIAICFPLR YPTIN..... TNMRMVLIIA
OLF202catfish QFVHYFATVN ALVLAVMAFD RYVAVCNPLR YVNIV..... KESTILGLCV
OLFCOR1chicken FSFVLLTVTE SLLLAVMAYD RYVAICKPLL YPSIM..... TKAVCWRLVE
OLFCOR2chicken FSFVLLTTSE WLLLAVMAYD RYVAICKPLL YPSIM..... TKAVCWRLVK
OLFCOR3chicken FSFVLLTTSE CLLLAVMAYD RYVAICKPLL YPAIM..... TKAVCWRLVE
OLFCOR4chicken FSFVLLTTSE CLLLAVMAYD RYVAICKPLL YPAIM..... TKAVCWRLVE
OLFCOR5chicken FSFVLLTSSE CLLLAVMAYD RYVAICKPLL YPAIM..... TKAVCWRLVE
OLFCOR6chicken FSFVLLTVRE CLLLAVMAYD RYAAICKPLL YPAIM..... TKAVCWRLVK
OLFdog YFFLFFGDLE SFLLVAMAYD RYVAICFPLH YTTIM..... SPKLCFSLLV
OLF07E YFLVSLVALD NLILAVMAYD RYVAICCPLH YTTAM..... SPKLCILLLS
OLF07I YFFLLFGDLE SFLLVAMAYD RYVAICFPLH YTAIM..... SPMLCLALVA
OLF07J FFFVTFGITN CFLLTAMGYD RYVAICNPLR YMVIM..... NKRLRIQLVL
OLFOR3mouse YVFLWLGATE CILLVVMAFD RYVAVCRPLH YMTVM..... NPRLCWGLAA
OLFrat FFFAIFVVTE GYLLTVMAYD RYVAICRPLL YNVIM..... SSRICSLLVL
OLFF3rat YFFLLFVELD NFLLTIMAYD RYVAICHPMH YTVIM..... NYKLCGFLVL
OLFF5rat YFLAVFGNMD NFLLAVMSYD RFVAICHPLH YTTKM..... TRQLCVLLVV
OLFF6rat YFVFSLGCTE YFLLAVMAYD RYLAICLPLR YGGIM..... TPGLAMRLAL
OLFF12rat CVFLVFAELG NFLLAVMAYD RYVAXCHPLC YTVIV..... NHRLCILLLL
OLFI3rat YFFMVFGDME SFLLVAMAYD RYVAICFPLH YTSIM..... SPKLCTCLVL
OLFI7rat YFFLGLGCTE CVLLAVMAYD RYVAICHPLH YPVIV..... SSRLCVQMAA
OLFI8rat FFFLLFGYLG NFLLVAMAYD RYVAICFPLH YTNIM..... SHKLCTCLLL
OLFI9rat YFFLFFGDLG NFLLVAMAYD RYVAICFPLH YMSIM..... SPKLCVSLVV
OLFI14rat YFFMVFGDME SFLLVVMAYD RYVAICFPLR YTTIM..... STKFCASLVL
OLFI15rat YFYLYFADLE SFLLVAMAYD RYVAICFPLH YMSIM..... SPKLCVSLVV
OLFOR17_40 FFFHLFVGVD CFLLTAMAYD QFLAICRPLT YSTRM..... SQTVQRMLVA
GUST27rat YFLTTFGGMD NFLLTLMACD RYVAICHPLN YTVI.....M NLQLCALLIL
RPE FQGFVTALAS ICSSAAIAWG RYHHYC.... .....TRSQL AWNSAVSLVL
HHRF1 ACFYVAMFAS LCFITEIALD RYYAIVY... .MRYR..... PVKQACLFSI
HHRF2 ACFYICLFAG VCFLINLSMD RYCVIVWGVE LNRVR..... NNKRATCWVV
HHRF3 VIYYSSCTVG FATVALIAAD RYRVLHKRTY ARQSY..... RSTYMIL..L
MCP-1A GLYHIGYFGG IFFIILLTID RYLAIVHAVF ALKAR..... TVTFGVVTSV
MCP-1B GLYHIGYFGG IFFIILLTID RYLAIVHAVF ALKAR..... TVTFGVVTSV
PPR1bovine ALYTVNFVSG MQFLACISTD RYWAVTKAPS QSGVG..... ..KPCWVICF
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GPCRAelegans GGWIFALVMA VVPLTGVSGY SKVAI..... .....CLPFD VSDATSTAYV
GRH LAWILSSVFA GPQLYIF..R MIHLADSSGQ .......... .TKVFSQCVT
TRH FVWAFTSLYC MLWFFLLDLN ISTYKDAIVI SCGYK..... ..........
FSHprec MGWIFAFAAA LFPIFGISSY M......... .KVSICLPMD IDS.......
TSHprec GGWVCCFLLA LLPLVGISSY A......... .KVSICLPMD TET.......
LH_CGprec GGWLFSSLIA MLPLVGVSNY M......... .KVSICFPMD VET.......
PGE_EP1 AVAAVALAVA LLPLARVG.. .....RYELQ YPGTWCFIGL GPPG......
PGE_EP2 AVYASNVLFC ALPNMGLGSS .......RLQ YPDTWCFIDW TTNVT.....
PGE_EP3 VIYAVSLLFC SLPLLDYG.. .....QYVQY CPGTWCFIRH GRT.......
PGF GVCLFAVFIA LLPILG.... ...HRDYKIQ ASRTWCFYNT EDIK......
PGI AIYAFCVLFC ALPLLGLG.. ..QHQQY... CPGSWCFLRM RWAQ......
TXA2 LVWAAALALG LLPLLGVG.. .....RYTVQ YPGSWCFLTL GA........
PAF VIWVAIVGAA SYFLILDSTN .........T VPDSAGSG.N | 