Molecular Recognition Section, Division of Intramural Research : NIDDK : National Institutes of Health

G Protein-Coupled Receptors

Welcome to the G Protein-Coupled Receptor Main Page of the Molecular Recognition Section.

Although our section is mainly involved in investigating the Molecular Recognition process between purinoceptors and their ligands, we are interested in all aspects of Molecular Recognition.

Since all currently known P1 purinoceptor subtypes, and several P2 purinoceptor subtypes are members of the protein family commonly known as G Protein-Coupled Receptors (GPCRs), we have collected a fair amount of data on GPCRs.

These data are organized in three sections:

The coordinates of our A2A adenosine receptor model (1MMH), and our P2Y1 receptor model (1DDD) are available from the Protein Data Bank.

The current release of the GPCR mutant database is version 3.2.1.

There is an informal network of groups trying to work out an international standard for GPCR database formats.

The institutes participating in this effort are:

our section at NIH
GCRdB at Harvard
GRAP at the University of Tromsø
Olfactory Receptor Database at Yale

Since this is a very dynamic field with lots of opportunities, we highly value your opinion of the current servers, what changes you would like to see made, or what new services you would like to see implemented.

Please drop us a note (e-mail or snail mail) at the address below.

Also, please read our disclaimer.

MRS Home Page
Selected Publications
Adenosine Receptors
P2 Receptors
Medicinal Chemistry
Computational Chemistry
The Purine Club

Chief: Dr. Kenneth Jacobson
The Molecular Recognition Section (MRS) is in the Laboratory of Bioorganic Chemistry at the National Institute of Diabetes and Digestive and Kidney Diseases which is part of the National Institutes of Health, Bethesda, MD, USA. General inquiries may be addressed to NIDDK, NIH, Building 31, Room 9A04, 31 Center Drive, MSC 2560, Bethesda, MD 20892-2560, USA.
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